Prognostic, screening and treatment methods and agents for treatment of metastasis and inflammation using 5t4 oncofoetal glycoprotein
作者： Vaskar Saha , Peter L. Stern
DOI:
关键词: Cell membrane 、 Inflammation 、 Treatment method 、 Immunology 、 Transmembrane Region 、 Chemotaxis 、 Biology 、 Metastasis 、 Cancer research 、 Glycoprotein 、 CXCR4
摘要: Methods and agents are disclosed based on the finding that 5T4 interacts with CXCR4 in cell membrane to form a complex, transmembrane region is involved promotion of expression chemotactic response.
lens.org 参考文章(62)
Barbara A. Sosnowski, Graham A. Fleurbaaij, Erwin Freund, Kimberly D. Victor, L. L. Houston, Michael P. Nova, Conjugates of vascular endothelial growth factor with targeted agents ,(1995)
Catherine D. Strader, Tung Ming Fong, Michael P. Grazlano, Michael R. Tota, The family of G-protein-coupled receptors. The FASEB Journal. ,vol. 9, pp. 745- 754 ,(1995) , 10.1096/FASEBJ.9.9.7601339
Mathis Heydtmann, Patricia F. Lalor, J. Albertus Eksteen, Stefan G. Hübscher, Mike Briskin, David H. Adams, CXC Chemokine Ligand 16 Promotes Integrin-Mediated Adhesion of Liver-Infiltrating Lymphocytes to Cholangiocytes and Hepatocytes within the Inflamed Human Liver Journal of Immunology. ,vol. 174, pp. 1055- 1062 ,(2005) , 10.4049/JIMMUNOL.174.2.1055
Ugo Cavallaro, Gerhard Christofori, Cell adhesion and signalling by cadherins and Ig-CAMs in cancer Nature Reviews Cancer. ,vol. 4, pp. 118- 132 ,(2004) , 10.1038/NRC1276
Karen W. King, Freda C. Sheppard, Caroline Westwater, Peter L. Stern, Kevin A. Myers, Organisation of the mouse and human 5T4 oncofoetal leucine-rich glycoprotein genes and expression in foetal and adult murine tissues. Biochimica et Biophysica Acta. ,vol. 1445, pp. 257- 270 ,(1999) , 10.1016/S0167-4781(99)00055-X
KF Bradstock, V Makrynikola, A Bianchi, W Shen, J Hewson, DJ Gottlieb, Effects of the chemokine stromal cell-derived factor-1 on the migration and localization of precursor-B acute lymphoblastic leukemia cells within bone marrow stromal layers. Leukemia. ,vol. 14, pp. 882- 888 ,(2000) , 10.1038/SJ.LEU.2401729
Yang Xu, Hong Lu, Jack P. Kennedy, Xuxia Yan, Laura A. McAllister, Noboru Yamamoto, Jason A. Moss, Grant E. Boldt, Shibo Jiang, Kim D. Janda, Evaluation of "credit card" libraries for inhibition of HIV-1 gp41 fusogenic core formation. ACS Combinatorial Science. ,vol. 8, pp. 531- 539 ,(2006) , 10.1021/CC0600167
Nicholas W. Lukacs, Aaron Berlin, Dominique Schols, Renato T. Skerlj, Gary J. Bridger, AMD3100, a CxCR4 antagonist, attenuates allergic lung inflammation and airway hyperreactivity. American Journal of Pathology. ,vol. 160, pp. 1353- 1360 ,(2002) , 10.1016/S0002-9440(10)62562-X
Thomas D. Southgate, Owen J. McGinn, Fernanda V. Castro, Andrzej J. Rutkowski, Mariam Al-Muftah, Georgi Marinov, Graeme J. Smethurst, David Shaw, Christopher M. Ward, Crispin J. Miller, Peter L. Stern, CXCR4 mediated chemotaxis is regulated by 5T4 oncofetal glycoprotein in mouse embryonic cells. PLOS ONE. ,vol. 5, ,(2010) , 10.1371/JOURNAL.PONE.0009982
Bostjan Kobe, Andrey V Kajava, The leucine-rich repeat as a protein recognition motif Current Opinion in Structural Biology. ,vol. 11, pp. 725- 732 ,(2001) , 10.1016/S0959-440X(01)00266-4