Prenylated Xanthones from the Roots of Cudrania tricuspidata as Inhibitors of Lipopolysaccharide-Stimulated Nitric Oxide Production.
作者： Yang Hee Jo , Seon Beom Kim , Qing Liu , Bang Yeon Hwang , Mi Kyeong Lee
关键词: Data interpretation 、 Nitric oxide 、 Chemistry 、 Organic chemistry 、 Two-dimensional nuclear magnetic resonance spectroscopy 、 Moiety 、 Cudrania tricuspidata 、 Stereochemistry 、 Ic50 values 、 Prenylation 、 Lipopolysaccharide
摘要: Investigation of the CH2Cl2 and EtOAc-soluble fractions roots Cudrania tricuspidata afforded 31 compounds. The structures isolated compounds were determined on basis spectroscopic data interpretation such as 1D 2D NMR analysis elucidated xanthones with prenyl moieties including four simple (1–4), five prenylated one moiety (5–7, 20, 21), 22 two (8–19 22–31). Among them, three diprenylated named cudracuspixanthones E–G (16, 29, 31) first in nature. Xanthones 2, 5, 6, 12, 19, 21, 22, 25, 27, 28 showed moderate inhibition lipopolysaccharide-stimulated nitric oxide production RAW 264.7 cells, IC50 values ranging from 16.1 to 24.8 µM.
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