Effect of naloxone and D-Met2-Pro5-enkephalinamide treatment on the DNA synthesis in the developing rat brain
作者： Zsuzsanna Vértes , Gy. Melegh , Marietta Vértes , S. Kovács
DOI: 10.1016/0024-3205(82)90423-4
关键词: Endocrinology 、 Cerebellum 、 DNA synthesis 、 (+)-Naloxone 、 Rat brain 、 Hypothalamus 、 DNA 、 Internal medicine 、 Forebrain 、 Enkephalin 、 Medicine 、 General Pharmacology, Toxicology and Pharmaceutics 、 General Biochemistry, Genetics and Molecular Biology 、 General Medicine
摘要: Effects of a single dose naloxone and D-Met2-Pro5-enkephalinamide on the DNA synthesis in forebrain, hypothalamus cerebellum 11 day old female rats were studied. As an index rate incorporation 3H-thymidine into was measured 30 min after sc. injection 40 muCi/100 g b.w.. A time dependent effect administration cerebral observed. In forebrain at 1 3 hrs increased found followed by marked decrease 9 12 hrs. The similar but initial increase hr absent. On cerebellar had no effect. resulted reduction labelling hypothalamic between to Except cerebellum.
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