Disruption of Circadian Rhythms and Gut Motility: An Overview of Underlying Mechanisms and Associated Pathologies.

摘要: Circadian rhythms ensure that physiological processes occur at the most biologically meaningful time. The circadian timing in gastrointestinal tract involves interlocking transcriptional and translational feedback loops culminate rhythmic expression activity of a set clock genes related hormones. suprachiasmatic nucleus peripheral core molecular clocks oscillate every 24 hours are responsible for periodic various segments transit along tract. Environmental cues may alter or reset these to align them with new circumstances. Colonic motility also follows rhythm reduced nocturnal activity. Healthy humans have normal bowel during day, frequently following awakening meal, minimal night. Maladjusted been linked digestive pathologies, including constipation irritable syndrome. Our advanced knowledge link between physiology provides potential therapeutic approaches treatment diseases. This review seeks establish evidence correlation rhythm, movements health, examine implications disrupted on gut physiology.