Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia.
作者： A Sanchez-Aguilera , I Rattmann , D Z Drew , L U W Müller , V Summey
DOI: 10.1038/LEU.2009.217
关键词: Protein kinase B 、 Haematopoiesis 、 Cancer research 、 Thymocyte 、 breakpoint cluster region 、 ZAP70 、 Biology 、 CD5 、 Chronic lymphocytic leukemia 、 Leukopoiesis
摘要: RhoH is a hematopoietic-specific, GTPase-deficient member of the Rho GTPase family that functions as regulator thymocyte development and T-cell receptor signaling by facilitating localization zeta-chain-associated protein kinase 70 (ZAP70) to immunological synapse. Here we investigated function in B-cell lineage. (BCR) was intact Rhoh(-/-) mice. Because interacts with ZAP70, which prognostic factor chronic lymphocytic leukemia (CLL), analyzed mRNA levels primary human CLL cells showed 2.3-fold higher expression compared normal B cells. positively correlated ZAP70. Deletion Rhoh murine model (Emu-TCL1(Tg) mice) significantly delayed accumulation CD5(+)IgM(+) leukemic peripheral blood burden peritoneal cavity, bone marrow spleen mice their Rhoh(+/+) counterparts. Phosphorylation AKT ERK response BCR stimulation notably decreased Emu-TCL1(Tg);Rhoh(-/-) splenocytes. These data suggest has progression show altered samples.
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sci-hub.se 参考文章(29)
Laura Pasqualucci, Peter Neumeister, Tina Goossens, Gouri Nanjangud, R. S. K. Chaganti, Ralf Küppers, Riccardo Dalla-Favera, Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas Nature. ,vol. 412, pp. 341- 346 ,(2001) , 10.1038/35085588
David A. Williams, Yi Zheng, Jose A. Cancelas, Rho GTPases and Regulation of Hematopoietic Stem Cell Localization Methods in Enzymology. ,vol. 439, pp. 365- 393 ,(2008) , 10.1016/S0076-6879(07)00427-2
L. Turka, E. A. Clark, N. S. C. Van Oers, A. Tran, J. C. Ryan, J. C. Ryan, A. Weiss, A. C. Chan, Che-Leung Law, Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling. Journal of Immunology. ,vol. 152, pp. 4758- 4766 ,(1994)
Kevin E. Draves, Christine M. Disteche, Edward A. Clark, Karen A. Chandran, Arthur Weiss, Svetlana P. Sidorenko, Susanne Edelhoff, Che Leung Law, Andrew C. Chan, Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex. Journal of Biological Chemistry. ,vol. 269, pp. 12310- 12319 ,(1994) , 10.1016/S0021-9258(17)32717-5
J S Brugge, K E Zoller, I A MacNeil, PROTEIN TYROSINE KINASES SYK AND ZAP-70 DISPLAY DISTINCT REQUIREMENTS FOR SRC FAMILY KINASES IN IMMUNE RESPONSE RECEPTOR SIGNAL TRANSDUCTION Journal of Immunology. ,vol. 158, pp. 1650- 1659 ,(1997)
Antonella Stoppacciaro, Anna Maria Lavinia, Maria Grazia Narducci, Edoardo Pescarmona, Sabina Signoretti, Cristina Lazzeri, Enrico Scala, Carlo David Baroni, Carlo Maria Croce, Giandomenico Russo, Daniele Remotti, Regulation of TCL1 Expression in B- and T-Cell Lymphomas and Reactive Lymphoid Tissues Cancer Research. ,vol. 60, pp. 2095- 2100 ,(2000)
Geert Molenberghs, Geert Verbeke, Linear Mixed Models for Longitudinal Data ,(2000)
Liguang Chen, John Apgar, Lang Huynh, Frank Dicker, Teresa Giago-McGahan, Laura Rassenti, Arthur Weiss, Thomas J. Kipps, ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia. Blood. ,vol. 105, pp. 2036- 2041 ,(2005) , 10.1182/BLOOD-2004-05-1715
Nicholas Chiorazzi, Kanti R. Rai, Manlio Ferrarini, Chronic lymphocytic leukemia. The New England Journal of Medicine. ,vol. 352, pp. 804- 815 ,(2005) , 10.1056/NEJMRA041720
Gianluca Gaidano, Laura Pasqualucci, Daniela Capello, Eva Berra, Clara Deambrogi, Davide Rossi, Luigi Maria Larocca, Annunziata Gloghini, Antonino Carbone, Riccardo Dalla-Favera, Aberrant somatic hypermutation in multiple subtypes of AIDS-associated non-Hodgkin lymphoma Blood. ,vol. 102, pp. 1833- 1841 ,(2003) , 10.1182/BLOOD-2002-11-3606