Cytogenetics of multiple endocrine neoplasia syndrome: II. Chromosome abnormalities in an insulinoma and a glucagonoma from two subjects with MEN1
作者： Susi Scappaticci , Maria Luisa Brandi , Elena Capra , Michela Cortinovis , Paola Maraschio
DOI: 10.1016/0165-4608(92)90057-F
关键词: Cytogenetics 、 Biology 、 Double minute 、 Multiple endocrine neoplasia 、 Insulinoma 、 MEN1 、 Glucagonoma 、 Chromosome 、 Internal medicine 、 Endocrinology 、 Pancreatic disease 、 Pathology
摘要: Cytogenetic analysis of two pancreatic islet tumors, an insulinoma and a glucagonoma was ascertained in subjects with multiple endocrine neoplasia type 1 (MEN1). The had modal peak at 84 chromosomes. Most cells were pseudotetraploid, all the normal chromosomes represented varied numbers, i.e., from to 7 copies. tumor 5 characteristic consistent marker which identified as deletions 1, 2, 7, 16, 17. All metaphases several double minute (dmin) variable size possible intermediate structures between dmin homogeneously staining chromosomal regions. nearly equal proportion structural numerical abnormalities no trend.
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