Menin interacting proteins as clues toward the understanding of multiple endocrine neoplasia type 1.

摘要: Multiple endocrine neoplasia type 1 (MEN1) is a familial cancer syndrome characterized mostly by tumors of the parathyroids, pancreas and anterior pituitary. The gene responsible, MEN1, encodes Menin, 610 aminoacid nuclear protein with no sequence homology to other proteins. Although mouse knock-out model available, function Menin still elusive. Proteins known are shown interact Menin: JunD, factor-KappaB, Smad3, Pem, Nm23H1, glial fibrillary acidic protein, Vimentin, probably P53. Their partnership may correspond regulation their activity, but relevance various traits MEN1 pathogenicity not established. This raises fundamental issues on pathways implicated in this complex disease.