RESPONSE OF HUMAN-IMMUNODEFICIENCY-VIRUS-ASSOCIATED NEUROLOGICAL DISEASE TO 3'-AZIDO-3'-DEOXYTHYMIDINE
作者： Robert Yarchoan , Pim Brouwers , A. Robert Spitzer , Jordan Grafman , Bijan Safai
DOI: 10.1016/S0140-6736(87)91968-4
关键词: Chemotherapy 、 Medicine 、 Viral disease 、 Peripheral neuropathy 、 Surgery 、 Physical examination 、 Gastroenterology 、 Dementia 、 Disease 、 Paraplegia 、 Internal medicine 、 Zidovudine 、 General Medicine
摘要: Abstract Four patients with human-immunodeficiency-virus-associated neurological disease were treated 3'-azido-3'-deoxythymidine (AZT). Three (two chronic dementia, and one dementia peripheral neuropathy) improved as assessed by clinical examination, psychometric tests, nerve conduction studies, and/or positron emission tomography; there was no improvement in the fourth patient who presented paraplegia. These results support hypothesis that certain AIDS-virus-associated abnormalities are reversible antiretroviral chemotherapy.
elsevier.com
sci-hub.se 参考文章(11)
Bradford A. Navia, Eun-Sook Cho, Carol K. Petito, Richard W. Price, The AIDS dementia complex: II. Neuropathology Annals of Neurology. ,vol. 19, pp. 525- 535 ,(1986) , 10.1002/ANA.410190603
George M Shaw, Mary E Harper, Beatrice H Hahn, Leon G Epstein, D Carleton Gajdusek, Richard W Price, Bradford A Navia, Carol K Petito, Carl J O'Hara, Jerome E Groopman, Eun-Sook Cho, James M Oleske, Flossie Wong-Staal, Robert C Gallo, HTLV-III infection in brains of children and adults with AIDS encephalopathy Science. ,vol. 227, pp. 177- 182 ,(1985) , 10.1126/SCIENCE.2981429
L. M. McDonough, D. A. George, B. A. Butt, J. M. Ruth, K. R. Hill, Sex Pheromone of the Codling Moth: Structure and Synthesis Science. ,vol. 177, pp. 177- 178 ,(1972) , 10.1126/SCIENCE.177.4044.177
R. Gallo, M Popovic, S Gartner, P Markovits, D. Markovitz, M. Kaplan, The role of mononuclear phagocytes in HTLV-III/LAV infection Science. ,vol. 233, pp. 215- 219 ,(1986) , 10.1126/SCIENCE.3014648
H. Mitsuya, K. J. Weinhold, P. A. Furman, M. H. St Clair, S. N. Lehrman, R. C. Gallo, D. Bolognesi, D. W. Barry, S. Broder, 3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 82, pp. 7096- 7100 ,(1985) , 10.1073/PNAS.82.20.7096
RaymondW. Klecker, PhillipD. Markham, DavidT. Durack, S.Nusinoff Lehrman, DavidW. Barry, MargaretA. Fischl, RobertC. Gallo, DaniP. Bolognesi, Samuel Broder, Robert Yarchoan, KentJ. Weinhold, H.Kim Lyerly, Edward Gelmann, RobertM. Blum, GeneM. Shearer, Hiroaki Mitsuya, JerryM. Collins, CharlesE. Myers, ADMINISTRATION OF 3'-AZIDO-3'-DEOXYTHYMIDINE, AN INHIBITOR OF HTLV-III/LAV REPLICATION, TO PATIENTS WITH AIDS OR AIDS-RELATED COMPLEX The Lancet. ,vol. 327, pp. 575- 580 ,(1986) , 10.1016/S0140-6736(86)92808-4
Raymond W Klecker, Jerry M Collins, Robert Yarchoan, Rose Thomas, Jean F Jenkins, Samuel Broder, Charles E Myers, Plasma and cerebrospinal fluid pharmacokinetics of 3′-azido-3′-deoxythymidine: A Novel pyrimidine analog with potential application for the treatment of patients with AIDS and related diseases Clinical Pharmacology and Therapeutics. ,vol. 41, pp. 407- 412 ,(1987) , 10.1038/CLPT.1987.49
Bradford A. Navia, Barry D. Jordan, Richard W. Price, The AIDS dementia complex: I. Clinical features. Annals of Neurology. ,vol. 19, pp. 517- 524 ,(1986) , 10.1002/ANA.410190602
David D. Ho, Teresa R. Rota, Robert T. Schooley, Joan C. Kaplan, J. Davis Allan, Jerome E. Groopman, Lionel Resnick, Donna Felsenstein, Charla A. Andrews, Martin S. Hirsch, Isolation of HTLV-III from Cerebrospinal Fluid and Neural Tissues of Patients with Neurologic Syndromes Related to the Acquired Immunodeficiency Syndrome The New England Journal of Medicine. ,vol. 313, pp. 1493- 1497 ,(1985) , 10.1056/NEJM198512123132401
Lionel Resnick, Fulvia diMarzo-Veronese, Jörg Schüpbach, Wallace W. Tourtellotte, David D. Ho, Franco Müller, Paul Shapshak, Markus Vogt, Jerome E. Groopman, Phillip D. Markham, Robert C. Gallo, Intra-blood-brain-barrier synthesis of HTLV-III-specific IgG in patients with neurologic symptoms associated with AIDS or AIDS-related complex. The New England Journal of Medicine. ,vol. 313, pp. 1498- 1504 ,(1985) , 10.1056/NEJM198512123132402