The in vivo effects of interleukin 1. I. Bone marrow cells are induced to cycle after administration of interleukin 1.

摘要: We have previously reported that interleukin 1 (IL-1) administration 20 hr before irradiation protects mice from lethal effects of radiation. The recovery total nucleated bone marrow cells and hematopoietic progenitor was enhanced in IL-1 treated, as compared to untreated, irradiated mice. This suggested may affect the normal Intraperitoneal recombinant resulted cell enlargement increased cycling these enlarged cells. In addition, capacity treated proliferate response granulocyte macrophage-colony-stimulating factor (GM-CSF) suspension cultures enhanced. above were not genetically restricted C57BL/6, B6D2F1, C3H/HeN, C3H/HeJ showed similar responses. A comparative study 100 ng much more effective stimulating by criteria than 5 micrograms GM-CSF. Since IL-1, unlike CSF, can be demonstrated a direct vitro stimulatory effect on cells, aforementioned vivo are presumably mediated other growth factors. shown induces appearance high titers CSF serum. Consequently factors generated at local sites following mediate observed effect.