Corticotropin-releasing hormone in health and disease: an update.

摘要: Corticotropin-releasing hormone (CRH) was initially sequenced and identified in 1981, has since become established as the principal organizer of stress response. It causes activation pituitary-adrenal axis, behavioural arousal, sympathetic stimulation a decrease appetite. In vitro studies have shown regulation hypothalamic CRH by variety neuro-transmitters, including cytokines interleukin-1 interleukin-6. However, circulating is mainly derived from extra-hypothalamic sites, levels may be elevated patients with tumours secreting ectopic CRH. The placenta further source CRH, which specifically raised pre-eclampsia, could factor initiation parturition. recently binding protein play vital role this process. Clinically, testing extremely useful diagnosis differential Cushing's syndrome, particularly for localization ACTH following inferior petrosal sinus catheterization. There considerable evidence that many depressive illness disturbance central control increasing importance therapy common condition. are also intriguing new data suggesting abnormalities involved pathogenesis inflammatory arthritis.