Evidence for a frontocortical-septal glutamatergic pathway and compensatory changes in septal glutamate uptake after cortical and fornix lesions in the rat
作者： George E. Jaskiw , Yousef Tizabi , Barbara K. Lipska , Bhaskar S. Kolachana , Richard Jed Wyatt
DOI: 10.1016/0006-8993(91)90398-F
关键词: Neurotransmitter 、 Nucleus accumbens 、 Fornix 、 Cerebral cortex 、 Biology 、 Glutamatergic 、 Lesion 、 Central nervous system 、 Anatomy 、 Glutamate receptor
摘要: Abstract To determine the source of glutamatergic input to septum and nucleus accumbens septi, glutamate uptake was assessed after transections frontal cortex and/or fornix. Uptake in reduced by 25 30% respectively, 6 days bilateral transections. Both indices returned control levels 30 postoperatively. In contrast, while unilateral fornix transection did not affect at either day or 30, significantly (25–35%) both times. When a performed rats with pre-existing ablation cortex, further reduction observed (50–60% transection). The data implicate as neurotransmitter frontocortico-septal projections suggest that contribution hippocampo-septal system total is increased following system.
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