Endothelin in Hypertension and Vascular Hypertrophy: Experimental Studies
作者： E. L. Schiffrin
DOI: 10.1007/978-3-642-79803-0_6
关键词: Endothelium 、 Thrombin 、 Endothelins 、 Internal medicine 、 Bradykinin 、 Endothelin receptor 、 Chemistry 、 Endocrinology 、 Pathophysiology of hypertension 、 Angiotensin II 、 Vasopressin
摘要: Endothelins are structurally related peptides with powerful vasoconstrictor properties [1]. Endothelin-1 was initially isolated from the endothelium [1], whereas structure of endothelin-2 and -3 deduced their cDNAs [2]. known today to be synthetized by many tissues [3–5]. In blood vessels, endothelin-1 is produced both in [1, 2] smooth muscle cells [6]. Release stimulated low shear stress [7], hypoxia, thrombin, angiotensin II, vasopressin, norepinephrine, bradykinin transforming growth factor β-1 (TGFβ-1) 8, 9]. High a potent inhibitor secretion [10].
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