Plasma immunoreactive endothelin-1 in experimental malignant hypertension.
作者： M Kohno , K Murakawa , T Horio , K Yokokawa , K Yasunari
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摘要: We measured plasma concentrations of immunoreactive endothelin-1 (irET-1) in the prehypertensive and hypertensive phases spontaneously rats (SHR) malignant hypertension caused by deoxycorticosterone acetate (DOCA)-salt administration SHR. also this peptide another model hypertension, two-kidney, one clip (2K1C) renovascular chronically given caffeine. Plasma irET-1 young (6-week-old) mature (18-week-old) SHR did not differ from those age-matched Wistar-Kyoto (WKY) rats. Four weeks treatment with DOCA-salt increased blood pressure, urea nitrogen, serum creatinine, but WKY Eight further these values were 2K1C Six caffeine renin activity, sham-operated High-performance liquid chromatographic profiles extracts pooled showed that a major component eluted position synthetic ET-1 (1-21). Furthermore, acute induced angiotensin II or phenylephrine affect concentration The results suggested is rat models high pressure itself main factor involved increase ET-1.
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