Seizures in oligodendroglial tumors

摘要: Epilepsy develops in more than 70-90% of oligodendroglial tumors and represents a favorable indicator for long-term survival if present as the first clinical sign. Presence IDH1 mutation is frequently associated with seizures oligodendrogliomas, next to alterations glutamate GABA metabolism origin glioma-associated epilepsy. Treatment by surgery or radiotherapy results seizure freedom about two-thirds patients, chemotherapy reduction 50%. Symptomatic anticonvulsive therapy levetiracetam valproic acid monotherapy are both evidence-based drugs partial epilepsies, their effective use brain supported large amount additional data. Pharmacoresistance against anticonvulsants prevalent among occurring 40% despite polytherapy two more. Toxic signs involve cognition, bone marrow skin. Previous neurosurgery, radiation add risks cognitive dysfunction.