Anabolic-androgenic steroids for alcoholic liver disease.

摘要: Background Alcohol is one of the most common causes liver disease in Western World. Randomised clinical trials have examined effects anabolic-androgenic steroids for alcoholic disease. Objectives To assess beneficial and harmful patients with based on results randomised trials. Search methods We searched The Cochrane Hepato-Biliary Group Controlled Trials Register, Register Library, MEDLINE, EMBASE, LILACS, Science Citation Index Expanded until June 2006. Electronic searches were combined full text searches. Manufacturers researchers field also contacted. Selection criteria Randomised studying steatosis, fibrosis, hepatitis, and/or cirrhosis included. Interventions encompassed at any dose or duration versus placebo no intervention. could be double blind, single unblinded. unpublished published, language limitations applied. Data collection analysis Outcomes are assessed maximal follow-up. All analyses performed according to intention-to-treat method. statistical package RevMan Analyses was used. methodological quality assessed. Main results Combining five randomising 499 hepatitis demonstrated significant mortality (relative risk (RR) 1.01, 95% confidence interval (CI) 0.79 1.29), liver-related (RR 0.83, CI 0.60 1.15), complications 1.25, 0.74 2.10), histology. Anabolic-androgenic did not significantly affect a number other outcome measures, including sexual function biochemistry. associated increased non-serious adverse events 1.14, 0.50 2.59) serious 4.54, 0.57 36.30). Authors' conclusions This systematic review demonstrate clinically important outcomes (mortality, mortality, complications, histology) disease.