The influence of ethanol and liver disease on sex hormones and hepatic oestrogen receptors in women.

摘要: In contrast to the numerous studies of men, very few have been concerned with sex hormone disturbances in women chronic alcoholic and non-alcoholic liver diseases. The aim study was, evaluate effect ethanol dysfunction on menstrual cycle, serum concentrations hepatic oestrogen receptors women. premenopausal female alcoholics consumption increase frequency disturbances, abortions, miscarriages, while infertility is not frequent. Acute intoxication has only minor effects pituitary-gonadal hormones women, abuse lead reduced sulphated steroids, these changes may be seen before severe appeared. earlier occurrence menopause comparison normal controls, information insufficient or lacking regarding influence upon fertility, pregnancy outcome sexual behavior postmenopausal disease, main metabolism consist elevated oestrone binding globulin (SHBG) concentrations, steroid sulphates 5 alpha-dihydrotestosterone (DHT) are reduced, degree a major determinant for observed disturbances. presence high affinity, low capacity, specific (ER) confirmed using ligand assay (DCC), specificity analyses, sucrose gradient centrifugation. Furthermore, sensitivity an enzyme immunoassay improved enabling quantitative measurement ER 102 small biopsies from patients method suitable assessment tissue samples, can applied other tissues than liver. Patients diseases significantly lower this reduction determined by dysfunction, hepatitis active less important factors. importance observation physiology pathophysiology remains determined.