Effect of Aging on the Pharmacokinetics of Gastrointestinal Drugs

作者: U. Klotz

DOI: 10.1159/000072610

关键词: Gastrointestinal DrugsPharmacologyMedicinePharmacokinetics

摘要:

参考文章(52)
D. Fliser, I. Bischoff, A. Hanses, S. Block, M. Joest, E. Ritz, E. Mutschler, Renal handling of drugs in the healthy elderly. Creatinine clearance underestimates renal function and pharmacokinetics remain virtually unchanged. European Journal of Clinical Pharmacology. ,vol. 55, pp. 205- 211 ,(1999) , 10.1007/S002280050619
Antona J. Wagstaff, Paul Benfield, Jon P. Monk, Colloidal Bismuth Subcitrate Drugs. ,vol. 36, pp. 132- 157 ,(1988) , 10.2165/00003495-198836020-00002
Sudhir Gupta, P-Glycoprotein Expression and Regulation Drugs & Aging. ,vol. 7, pp. 19- 29 ,(1995) , 10.2165/00002512-199507010-00003
Jan Gunnar Hatlebakk, Arnold Berstad, Pharmacokinetic Optimisation in the Treatment of Gastro-Oesophageal Reflux Disease Clinical Pharmacokinectics. ,vol. 31, pp. 386- 406 ,(1996) , 10.2165/00003088-199631050-00005
Yuanchao Zhang, Leslie Z. Benet, The gut as a barrier to drug absorption: combined role of cytochrome P450 3A and P-glycoprotein. Clinical Pharmacokinectics. ,vol. 40, pp. 159- 168 ,(2001) , 10.2165/00003088-200140030-00002
B. FLOUVAT, B. DELHOTAL-LANDES, A. COURNOT, F. DELLATOLAS, Single and multiple dose pharmacokinetics of lansoprazole in elderly subjects. British Journal of Clinical Pharmacology. ,vol. 36, pp. 467- 469 ,(1993) , 10.1111/J.1365-2125.1993.TB00398.X
Margaret A. Winker, Aging: A Global Issue JAMA: The Journal of the American Medical Association. ,vol. 278, pp. 1377- 1377 ,(1997) , 10.1001/JAMA.1997.03550160097047
J. Sjovall, G. Alvan, B. Huitfeldt, Intra- and inter-individual variation in pharmacokinetics of intravenously infused amoxycillin and ampicillin to elderly volunteers British Journal of Clinical Pharmacology. ,vol. 21, pp. 171- 181 ,(1986) , 10.1111/J.1365-2125.1986.TB05172.X