Human immunodeficiency virus type 1 mother-to-child transmission and prevention: successes and controversies.

作者: M. Cavarelli , G. Scarlatti

DOI: 10.1111/J.1365-2796.2011.02458.X

关键词: Acquired immunodeficiency syndrome (AIDS)PediatricsTransmission (medicine)BreastfeedingMedicineVirologyPregnancyMother to child transmissionNevirapineHuman immunodeficiency virus (HIV)Regimen

摘要: Abstract.  Cavarelli M., Scarlatti G (Unit of Viral Evolution and Transmission, DITID, San Raffaele Scientific Institute). Human immunodeficiency virus type 1 mother-to-child transmission prevention: successes controversies (Symposium). J Intern Med 2011; doi: 10.1111/j.1365-2796.2011.02458.x. The World Health Organization (WHO) United Nations Programme on HIV/AIDS (UNAIDS) estimated that an additional 370 000 new human (HIV-1) infections occurred in children 2009, mainly through (MTCT). Intrapartum contributes to approximately 20–25% infections, utero 5–10% postnatal 10–15% cases. MTCT accounts for only a few hundred infected newborns those countries which services are established voluntary counselling testing pregnant women, supply antiretroviral drugs is available throughout pregnancy with recommendations elective Caesarean section avoidance breastfeeding. The single-dose nevirapine regimen has provided the momentum initiate programmes many resource-limited countries; however, regimens using combination needed also effectively reduce via

参考文章(197)
Lucia Ometto, Marisa Zanchetta, Monica Mainardi, Gian Luca De Salvo, Marie Cruz Garcia-Rodriguez, Linsay Gray, Marie Louise Newell, Luigi Chieco-Bianchi, Anita De Rossi, Co-receptor usage of HIV-1 primary isolates, viral burden, and CCR5 genotype in mother-to-child HIV-1 transmission. AIDS. ,vol. 14, pp. 1721- 1729 ,(2000) , 10.1097/00002030-200008180-00006
D.T Dunn, M.L Newell, A.E Ades, C.S Peckham, Risk of human immunodeficiency virus type 1 transmission through breastfeeding. The Lancet. ,vol. 340, pp. 585- 588 ,(1992) , 10.1016/0140-6736(92)92115-V
CHRISTINE DUPRAT, ZEENA MOHAMMED, PRATIBHA DATTA, WALTER STACKIW, JACKONIAH O. NDINYA-ACHOLA, JOAN K. KREISS, KING K. HOLMES, FRANCIS A. PLUMMER, JOANNE E. EMBREE, Human immunodeficiency virus type 1 IgA antibody in breast milk and serum. Pediatric Infectious Disease Journal. ,vol. 13, pp. 603- 608 ,(1994) , 10.1097/00006454-199407000-00004
Valériane Leroy, John M Karon, Ahmadou Alioum, Ehounou R Ekpini, Nicolas Meda, Alan E Greenberg, Philippe Msellati, Michael Hudgens, François Dabis, Stefan Z Wiktor, West Africa PMTCT Study Group, Twenty-four month efficacy of a maternal short-course zidovudine regimen to prevent mother-to-child transmission of HIV-1 in West Africa AIDS. ,vol. 16, pp. 631- 641 ,(2002) , 10.1097/00002030-200203080-00016
Saidi H. Kapiga, Wafaie W. Fawzi, Donna Spiegelman, Jenny Coley, Heejung Bang, David J. Hunter, Gernard I. Msamanga, Correlates of plasma HIV-1 RNA viral load among HIV-1-seropositive women in Dar es Salaam, Tanzania. Journal of Acquired Immune Deficiency Syndromes. ,vol. 30, pp. 316- 323 ,(2002) , 10.1097/01.QAI.0000014767.47046.C8
E. Menu, D. Dormont, P. Roques, G. Chaouat, B. Mognetti, M. Moussa, J. Croitoru, HIV-1 co-receptor expression on trophoblastic cells from early placentas and permissivity to infection by several HIV-1 primary isolates. Clinical and Experimental Immunology. ,vol. 119, pp. 486- 492 ,(2000) , 10.1046/J.1365-2249.2000.01149.X
James A. McIntyre, Mark Hopley, Daya Moodley, Marie Eklund, Glenda E. Gray, David B. Hall, Patrick Robinson, Douglas Mayers, Neil A. Martinson, Efficacy of Short-Course AZT Plus 3TC to Reduce Nevirapine Resistance in the Prevention of Mother-to-Child HIV Transmission: A Randomized Clinical Trial PLoS Medicine. ,vol. 6, pp. e1000172- ,(2009) , 10.1371/JOURNAL.PMED.1000172
Anastasia Polycarpou, Christos Ntais, Bette T. Korber, Henry A. Elrich, Robert Winchester, Paul Krogstad, Steven Wolinsky, Timothy Rostron, Sarah L. Rowland-Jones, Arthur J. Ammann, John P.A. Ioannidis, Association between maternal and infant class I and II HLA alleles and of their concordance with the risk of perinatal HIV type 1 transmission. AIDS Research and Human Retroviruses. ,vol. 18, pp. 741- 746 ,(2002) , 10.1089/08892220260139477
Homira Behbahani, Edwina Popek, Patricia Garcia, Jan Andersson, Anna-Lena Spetz, Alan Landay, Zareefa Flener, Bruce K. Patterson, Up-Regulation of CCR5 Expression in the Placenta Is Associated with Human Immunodeficiency Virus-1 Vertical Transmission American Journal of Pathology. ,vol. 157, pp. 1811- 1818 ,(2000) , 10.1016/S0002-9440(10)64819-5
F. J. E. DAVID, B. AUTRAN, H. C. TRAN, E. MENU, M. RAPHAEL, P. DEBRE, B. L. HSI, T. G. WEGMAN, F. BARRE-SINOUSSI, G. CHAOUAT, Human trophoblast cells express CD4 and are permissive for productive infection with HIV-1. Clinical and Experimental Immunology. ,vol. 88, pp. 10- 16 ,(2008) , 10.1111/J.1365-2249.1992.TB03031.X