Piper Essential Oils Inhibit Rhizopus oryzae Growth, Biofilm Formation, and Rhizopuspepsin Activity

摘要: Piper is the largest genus of Piperaceae family. The species this have diverse biological activities and are used in pharmacopeia throughout world. They also folk medicine for treatment many diseases several countries including Brazil, China, India, Jamaica, Mexico. In distributed national territory, making a good candidate activity screening. During our studies with essential oils, we evaluated its against Rhizopus oryzae, main agent mucormycosis. compounds seven oils analyzed were callosum—safrole (53.8%), P. aduncum—dillapiole (76.0%), hispidinervum—safrole (91.4%), marginatum—propiopiperone (13.2%), hispidum—γ-terpinene (30.9%), tuberculatum—(E)-caryophyllene (30.1%), sp.—linalool (14.6%). minimum inhibitory concentration R. oryzae ranged from 78.12 to >1250 μg/mL. best result total inhibition biofilm formation was obtained sp. starting 4.88 μg/mL. Considering bioactive potential EOs planktonic cells could be great interest development antimicrobials therapeutic use fungal infection.