Inhibitory effect of linalool-rich essential oil from Lippia alba on the peptidase and keratinase activities of dermatophytes.
作者： Danielle Cristina Machado Costa , Alane Beatriz Vermelho , Catia Amancio Almeida , Edilma Paraguai de Souza Dias , Sabrina Martins Lage Cedrola
DOI: 10.3109/14756366.2012.743537
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摘要: AbstractLippia alba (Miller) N.E. Brown is an aromatic plant known locally as “Erva-cidreira-do-campo” that has great importance in Brazilian folk medicine. The aim of our study was to evaluate the antidermatophytic potential linalool-rich essential oil (EO) from L. and analyze ability this EO inhibit peptidase keratinase activities, which are important virulence factors dermatophytes. minimum inhibitory concentrations (MICs) were 39, 156 312 µg/mL against Trichophyton rubrum, Epidermophyton floccosum Microsporum gypseum, respectively. To influence on proteolytic keratinolytic activities these dermatophytes, specific assays performed. results indicated inhibited activity proteases keratinases secreted inhibition could be a possible mechanism action Due effective ...
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