The viral approach to breast cancer immunotherapy.

摘要: Despite years of intensive research, breast cancer remains the leading cause death in women worldwide. New technologies including oncolytic virus therapies, virus, and phage display are among most powerful advanced methods that have emerged recent with potential applications prevention treatment. Oncolytic therapy is an interesting strategy for Presently, a number viruses from different families under laboratory clinical investigation as therapeutics. (OVs) been shown to be able induce initiate systemic antitumor immune response. The possibility application multimodal using combination OV checkpoint inhibitors antigen vaccination holds great promise future immunotherapy. Display immunologic peptides on bacterial (bacteriophages) also increasingly being considered new strong vaccine delivery strategy. In immunotherapy, peptide or protein presented by genetic fusions coat proteins, construct formulation acts protective preventive against cancer. our laboratory, we recently tested few (E75, AE37, GP2) derived HER2/neu proto-oncogene modalities treatment TUBO xenograft tumors BALB/c mice. Here, this paper, discuss latest advancements OVs systems