Alzheimer's Disease in Down Syndrome.
作者： Elizabeth Head , David Powell , Brian T Gold , Frederick A Schmitt
DOI:
关键词: Alzheimer's disease 、 Gerontology 、 Down syndrome 、 Age of onset 、 Pediatrics 、 Senile plaques 、 Neuropathology 、 Dementia 、 Cognitive decline 、 Psychology 、 Disease
摘要: A key challenge to adults with Down syndrome (DS) as they age is an increased risk for cognitive decline, dementia, and Alzheimer disease (AD). In DS persons ranging from 40-49 years of age, 5.7-55% may be clinically demented between 50-59 years, dementia prevalence ranges 4-55% (reviewed in [1]). Despite the wide reported prevalence, a consistent feature aging progressive accumulation AD brain pathologies. By 40 virtually all have sufficient senile plaques neurofibrillary tangles neuropathological diagnosis [2]. Thus, there dissociation onset neuropathology (40 years) increasing signs clinical dementia. We discuss hypothesis that frontal impairments are critical factor affecting function associated white matter (WM) neuropathology. While these early sign conversion we also review several other comorbidities contribute onset.
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