Arsenic Exposure, Arsenic Metabolism, and Incident Diabetes in the Strong Heart Study

摘要: OBJECTIVE Little is known about arsenic metabolism in diabetes development. We investigated the prospective associations of low-moderate exposure and with incidence Strong Heart Study. RESEARCH DESIGN AND METHODS A total 1,694 diabetes-free participants aged 45–75 years were recruited 1989–1991 followed through 1998–1999. used proportions urine inorganic (iAs), monomethylarsonate (MMA), dimethylarsinate (DMA) over their sum (expressed as iAs%, MMA%, DMA%) biomarkers metabolism. Diabetes was defined fasting glucose ≥126 mg/dL, 2-h ≥200 self-reported history, or use antidiabetic medications. RESULTS Over 11,263.2 person-years follow-up, 396 developed diabetes. Using leave-one-out approach to model dynamics metabolism, we found that lower MMA% associated higher incidence. The hazard ratios (95% CI) for a 5% increase 0.77 (0.63–0.93) 0.82 (0.73–0.92) when iAs% DMA%, respectively, left out model. DMA% only decreased (left model) but not decreased. also association between similar by age, sex, study site, obesity, iAs concentrations. CONCLUSIONS Arsenic particularly prospectively increased Research needed evaluate whether related per se its close connections one-carbon