Arsenic exposure is associated with diminished insulin sensitivity in non‐diabetic Amish adults

摘要: Background Substantial evidence supports an association between diabetes and arsenic at high exposure levels, but results are mixed low levels. The aetiology of involves insulin resistance β-cell dysfunction. However, only a few epidemiologic studies have examined measures function in relation to exposure, no tested for associations with the oral glucose tolerance test (OGTT). We urinary total OGTT-based markers sensitivity function. Methods studied 221 non-diabetic adults (mean age = 52.5 years) from Amish Family Diabetes Study. computed validated Generalized estimating equations accounting sibship were used estimate associations. Results After adjusting age, sex, waist-to-hip ratio creatinine, interquartile range increase (6.24 µg/L) was significantly, inversely associated two (Stumvoll metabolic clearance rate -0.23 mg/(kg min), (95% CI: -0.38, -0.089), p 0.0015; Stumvoll index -0.0029 µmol/(kg min pM), -0.0047, -0.0011), 0.0015). Urinary also significantly higher fasting levels (0.57 mg/dL 0.06, 1.09) per increase, 0.029). No significant found measures. Conclusions This preliminary study that not measures, suggesting low-level may influence risk through impairing sensitivity. Copyright © 2015 John Wiley & Sons, Ltd.