Association of type 1 diabetes and concentrations of drinking water components in Newfoundland and Labrador, Canada

摘要: Objective To determine the association between drinking water quality and rates of type 1 diabetes in Newfoundland Labrador (NL) population, which has one highest incidences reported globally. Research design methods The study used a community-based, case-control design. We first calculated incidence at provincial, regional community levels. connection components public supplies were then analyzed three ways: to evaluate differences communities with without incident cases diabetes, analyze relationship both Results provincial was 51.7/100 000 (0-14 year age group) for period studied. In community-based analysis, there significant associations found higher concentrations arsenic (β=0.268, P=0.013) fluoride (β=0.202, P=0.005) diabetes. barium (β=−0.478, P=0.009) nickel (β=−0.354, P=0.050) negatively associated Conclusions confirmed high NL. also that some but no component have across different levels analysis performed.