Effects of atorvastatin on postprandial plasma lipoproteins in postinfarction patients with combined hyperlipidaemia.

摘要: Abstract Enhanced and prolonged postprandial lipaemia is implicated in coronary carotid artery disease. This study assessed the effects of atorvastatin, a 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor, on plasma concentrations triglyceride-rich lipoproteins (TRLs). Sixteen middle-aged men with combined hyperlipidaemia (baseline low density lipoprotein (LDL) cholesterol triglyceride (median (interquartile range) 4.54 (4.17–5.26)) 2.66 (2.04–3.20) mmol/l, respectively) previous myocardial infarction were randomised to atorvastatin 40 mg or placebo once daily for 8 weeks double-blind, cross-over design. The apolipoprotein (apo) B-48 B-100 contents determined subfractions TRLs as measure chylomicron remnant very (VLDL) particle (expressed apo per litre plasma), fasting state after intake mixed meal. Atorvastatin treatment reduced significantly VLDL cholesterol, LDL triglycerides (median% change) by 29, 44 27%, respectively, increased high (HDL) 19%, compared baseline. large (Svedberg flotation rate (Sf) 60–400) small (Sf 20–60) VLDLs remnants almost halved baseline (mean 0–6 h 48% Sf 60–400 B-100, 46% B-48, 20–60 27% B-48), triglyceridaemia was 23% during active treatment. In conclusion, causes profound reductions all hyperlipidaemic patients premature