Quantification of uncertainties in conventional plan evaluation methods in Intensity Modulated Radiation Therapy.

摘要: PURPOSE: In Intensity Modulated Radiation Therapy (IMRT) dose distributions tend to be more complex and heterogeneous because of the modulated fluences in each beamlet every single beam. These dose-volume (DV) parameters derived from volume histogram (DVH) are physical quantities, thought correlate with biological response tissues. The aim this study was quantify uncertainty metrics predict clinical outcomes radiotherapy. METHODS: radiobiological estimates such as tumor control probability (TCP) Normal Tissue Complication Probability (NTCP) were made for a cohort 40 cancer patients (10 brain;19 head & neck;11 cervix) using DV parameters. Statistical analysis performed determine correlation plan quality indicators estimates. RESULTS: between conformity index (CI) TCP found good dosimetric optic nerves, chiasm, brain stem, normal parotids correlated well NTCP A follow up (median duration 18 months) also performed. There no grade 3 or 4 tissue complications observed. Local higher (90%) pelvic cases (95%), whereas decline 70% noted neck cases. CONCLUSIONS: equivalent uniform (EUD) concept model used software determines values which can precisely data voxel level. evaluation is quantified statistical analysis. Radiobiological helpful ranking rival treatment plans also.