NaCl solution ingestion in genetic (SHR) and aortic-ligation hypertension☆

摘要: Abstract Two types of rats with hypertension were investigated to clarify the relation between free ingestion NaCl solutions (0.5–3.0% NaCl) and established genetic (SHR Okamoto strain) renovascular (aortic ligation) hypertension. The acceptability was measured by rehydration drinking a single solution in 1-hr period. preference for allowing continuous access both water. Except at ends Nacl concentration range, more accepted preferred SHR strain comparison Wistar-Kyoto (WKY) controls. Water turnover not different WKY animals. In chronichypertension phase aortic-ligation, there no difference ligated sham-operated groups. middle range concentrations nonpreferred animals relative group. increased markedly several days post-operative period then descended. However, remained greater compared their A chronically elevated blood pressure, then, does itself appear produce an increase ingestion. fact, present results together other studies made during chronic indicate lack solutions. acceptance cannot be related etiology present.