Pilot study of reduced-intensity conditioning followed by allogeneic stem cell transplantation from related and unrelated donors in patients with myelofibrosis
作者： Nicolaus Kroger , Tatjana Zabelina , Heike Schieder , Jens Panse , Francis Ayuk
DOI: 10.1111/J.1365-2141.2005.05373.X
关键词: Donor lymphocyte infusion 、 Internal medicine 、 Surgery 、 Fludarabine 、 Transplantation 、 Myelofibrosis 、 Graft-versus-host disease 、 Lymphocyte 、 Confidence interval 、 Gastroenterology 、 Hematology 、 Medicine
摘要: Summary A prospective pilot study was performed to evaluate the effect of reduced-intensity conditioning with busulphan (10 mg/kg), fludarabine (180 mg/qm) and anti-thymocyte globulin followed by allogeneic stem cell transplantation from related (n = 8) unrelated donors (n = 13) in 21 patients myelofibrosis. The median age 53 years (range, 32–63). No primary graft failure occurred. time until leucocyte (>1·0 × 109/l) platelet (>20 × 109/l) engraftment 16 11–26) 23 d 9–139) respectively. Complete donor chimaerism on day 100 seen 20 (95%). Acute graft-versus-host disease (GvHD) grades II–IV III/IV occurred 48% 19% cases 55% had chronic GvHD. Treatment-related mortality 0% at 16% [95% confidence interval (CI): 0–32%] 1 year. Haematological response 100% complete histopathological remission observed 75% 25% showed partial a continuing decline grade fibrosis. After follow-up 22 months 4–59), 3-year estimated overall disease-free survival 84% (95% CI: 67–100%).
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