Acupuncture for the treatment of pediatric nocturnal enuresis: A systematic review and a meta-analysis of randomized and non-randomized studies

摘要: Abstract Introduction Nocturnal enuresis is a common clinical condition in the pediatric population. The aim of this study was to assess effectiveness acupuncture treatment on nocturnal enuresis. Methods search publications using “acupuncture” and “enuresis” or “bedwetting” as keywords performed 6 databases. To be included studies had (1) compare with conventional placebo; (2) investigate sample; (3) provide results at end follow-up. Languages were English; Italian; Chinese. Analysis according PRISMA guidelines. Primary outcome reduction wet nights. Side effects dropouts secondary outcomes. Results We 10 (7 randomized controlled trials 3 non-randomized trials) covering total 888 patients. A favorable, but non significant, effect compared care placebo emerged. type main source heterogeneity. No statistically significant differences emerged across studies. difference found dropouts. group minor rarely reported. Conclusions Acupuncture seems an effective option for enuresis, though further large are needed because no significance low quality might have overestimated results. feasible side effects.