Release of GM-CSF and G-CSF by human arterial and venous smooth muscle cells: differential regulation by COX-2.

摘要: In addition to their traditional contractile function, vascular smooth muscle cells can be stimulated under inflammatory conditions release a range of potent biological mediators. Indeed, we and others have shown that human the colony stimulating factors (CSF) granulocyte macrophage-CSF (GM-CSF) granulocyte-CSF (G-CSF) as well large amounts prostaglandins following induction cyclo-oxygenase-2 (COX-2), when with cytokines. Here demonstrate, for first time, co-induced COX-2 activity simultaneously suppresses GM-CSF potentiates G-CSF by cells. Moreover, differential regulation was mimicked prostacyclin (PGI2) mimetic, cicaprost. These observations suggest PGI2, released COX-2, differentially regulates (suppresses) (potentiates) from cells. British Journal Pharmacology (2000) 129, 835–838; doi:10.1038/sj.bjp.0703151