Substituted heterocyclic compounds

作者: Venkata Palle , Jeff Zablocki

DOI:

关键词: DiseaseAnginaMyocardial infarctionDiabetes mellitusCongestive heart diseaseCardiologyPlasma levelsUnstable anginaInternal medicineMedicineIntermittent claudication

摘要: Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable unstable exercise induced congestive heart disease, myocardial infarction. The compounds also diabetes, increasing HDL plasma levels mammals.

参考文章(99)
Andrew Fensome, Marci Koko, Jay Wrobel, Puwen Zhang, Zhiming Zhang, Jeffrey Cohen, Scott Lundeen, Kelly Rudnick, Yuan Zhu, Richard Winneker, Novel 5-aryl-1,3-dihydro-indole-2-thiones. potent, orally active progesterone receptor agonists. Bioorganic & Medicinal Chemistry Letters. ,vol. 13, pp. 1317- 1320 ,(2003) , 10.1016/S0960-894X(03)00129-X
David V. Goeddel, Siao Ping Tsai, Brian D. Bennett, William Matthews, James M. Lee, William I. Wood, SAL-S1 receptor protein tyrosine kinase agonist antibodies ,(2001)
Makoto Odate, Nobuyuki Fukazawa, Tsuneji Suzuki, Kengo Otsuka, Wakao Sato, Takashi Tsuruo, Heterocyclic compounds and anticancer-drug potentiaters conaining them as effective components ,(1991)
Wenrong Huang, Bing-Yan Zhu, Penglie Zhang, Robert M. Scarborough, Isoindole and isoquinoline derivatives as inhibitors of factor xa ,(2002)
Kevin R. Anderson, Ila Sircar, 2-substituted-1,4-dihydropyridines ,(1987)
Bodo Junge, Thomas Glaser, Reilinde Wittka, Hans-Georg Heine, Frank Mauler, Jean-Marie-Viktor De Vry, Klaus Urbahns, Substituted 4H-pyrans ,(1996)
Brent Blackburn, Hani Sabbah, Method of reversing left ventricular remodeling ,(2005)
David Philip Rooker, Michael Bryan Roe, Gary Robert William Pitt, Celine Marguerite Simone Heeney, Peter Jeremy Hudson, Andrzej Roman Batt, Diazacycloalkanes as oxytocin agonists ,(2002)
Howard M. Reisner, Composition to treat diabetes ,(2001)
Tim Marquart, Elfatih Elzein, Prabha N. Ibrahim, Jeff Zablocki, Venkata P. Palle, Brent K. Blackburn, Aralkyl substituted piperazine compounds ,(2001)