Novel 5-aryl-1,3-dihydro-indole-2-thiones. potent, orally active progesterone receptor agonists.
作者： Andrew Fensome , Marci Koko , Jay Wrobel , Puwen Zhang , Zhiming Zhang
DOI: 10.1016/S0960-894X(03)00129-X
关键词:
摘要: During the course of our studies on 3,3-disubstituted-5-aryloxindoles derived progesterone receptor (PR) antagonists we discovered that changing amide funtionality to a thio-amide resulted in compounds displaying potent PR agonist activity. In this communication, synthesis, structure activity relationships (SAR) and vivo various 5-arylthio-oxindoles will be discussed.
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