A comparison of the acute toxicity of chemicals to fish, rats and mice

摘要: The acute toxicity of chemicals to rainbow trout, as shown by intraperitoneal injections (IP LD50), oral dosing (oral LD50) and aqueous exposure (LC50) was compared with published values for IP LD50s mice rats. method comparison simple linear regression analyses log-transformed data, modified recognize that X (fish toxicity) neither fixed nor measured without error. Within-species comparisons demonstrated very strong correlations (r =0.866–0.998) between LD50s. Variability least the fish data since it all generated in one laboratory. Comparisons species LD50S gave correlation coefficients ranging from 0.59 0.95 majority over 0.80. Correlations were best =0.83–0.94) rat poorest mammalian =0.59–0.66) because sample sizes ranges small. In cases, slopes close to, or equalled, 1.0. Comparisons LC50s not successful. Correlation ranged 0.19 0.83. Presumably cause exposure. Interactions water (e.g. dissociation) lipid membranes (partitioning) should considerable variations uptake efficiency. However, adjustments dissociation constants partition did improve these correlations, probably there few which available. These demonstrate a potential wider use surrogate testing adapting existing toxicology aquatic hazard assessments.