Characterization of Breast Cancer Tissue From a Rat Model With and Without Cancer: The Use of Raman Spectroscopy

作者: L. Rocha-Osornio , J. L. Pichardo-Molina , G. Barbosa-Sabanero , J. M. de la Roca , C. Frausto-Reyes

DOI: 10.1080/00387010.2014.895386

关键词: BiopsyRat modelEarly detectionChemistryPathologyBreast tumorBreast tissueRaman spectroscopyBreast cancerCancerAnalytical chemistry

摘要: Micro-Raman spectroscopy was performed on normal and tumor breast tissue of rats. Our results have shown that the strength Raman spectra intensity can be useful to differentiate between tissues. Also, fingerprint biochemical markers makes possible automatic discrimination classification abnormal tissue. For this evaluation, principal component analysis generalized linear discriminate were used. From our results, we believe rat model cancer helpful understanding molecular changes its early detection.

参考文章(40)
Aline S. de Aluja, Animales de laboratorio y la Norma Oficial Mexicana (NOM-062-ZOO-1999) Gaceta Medica De Mexico. ,vol. 138, pp. 295- 298 ,(2002)
Hans-Ulrich Gremlich, Bing Yan, None, Infrared and Raman Spectroscopy of Biological Materials ,(2000)
Rina K. Dukor, Vibrational Spectroscopy in the Detection of Cancer Handbook of Vibrational Spectroscopy. ,(2006) , 10.1002/0470027320.S8107
Janina Kneipp, Tom Bakker Schut, Mike Kliffen, Marian Menke-Pluijmers, Gerwin Puppels, Characterization of breast duct epithelia: a Raman spectroscopic study Vibrational Spectroscopy. ,vol. 32, pp. 67- 74 ,(2003) , 10.1016/S0924-2031(03)00048-1
Jagdish S Thakur, Houbei Dai, Gulay K Serhatkulu, Ratna Naik, Vaman M Naik, Alex Cao, Abhilash Pandya, Gregory W Auner, Rajah Rabah, Michael D Klein, Carl Freeman, None, Raman spectral signatures of mouse mammary tissue and associated lymph nodes: normal, tumor and mastitis Journal of Raman Spectroscopy. ,vol. 38, pp. 127- 134 ,(2007) , 10.1002/JRS.1565
M. V. P. Chowdary, K. Kalyan Kumar, Jacob Kurien, Stanley Mathew, C. Murali Krishna, Discrimination of normal, benign, and malignant breast tissues by Raman spectroscopy Biopolymers. ,vol. 83, pp. 556- 569 ,(2006) , 10.1002/BIP.20586
Abdullah Chandra Sekhar Talari, Zanyar Movasaghi, Shazza Rehman, Ihtesham ur Rehman, Raman spectroscopy of biological tissues Applied Spectroscopy Reviews. ,vol. 42, pp. 493- 541 ,(2007) , 10.1080/05704928.2014.923902
Anita Mahadevan-Jansen, Rebecca R Richards-Kortum, Raman spectroscopy for the detection of cancers and precancers Journal of Biomedical Optics. ,vol. 1, pp. 31- 70 ,(1996) , 10.1117/12.227815
K. Kalyan Kumar, M. V. P. Chowdary, Stanley Mathew, Lakshmi Rao, C. Murali Krishna, Jacob Kurien, Raman spectroscopic diagnosis of breast cancers: Evaluation of models Journal of Raman Spectroscopy. ,vol. 39, pp. 1276- 1282 ,(2008) , 10.1002/JRS.1991
J. L. Pichardo-Molina, C. Frausto-Reyes, O. Barbosa-García, R. Huerta-Franco, J. L. González-Trujillo, C. A. Ramírez-Alvarado, G. Gutiérrez-Juárez, C. Medina-Gutiérrez, Raman spectroscopy and multivariate analysis of serum samples from breast cancer patients. Lasers in Medical Science. ,vol. 22, pp. 229- 236 ,(2007) , 10.1007/S10103-006-0432-8