Rescue of rats from large dose cyclophosphamide toxicity using protein A.
作者： Prasanta K. Ray , Mariam Dohadwala , Santu K. Bandyopadhyay , Pramook Canchanapan , Denise McLaughlin
DOI: 10.1007/BF00552727
关键词: Cytotoxic drug 、 Pharmacology toxicology 、 Toxicity 、 Cyclophosphamide 、 Large dose 、 Therapeutic index 、 Protein A 、 Medicine 、 Pharmacology 、 Staphylococcus aureus
摘要: Cyclophosphamide (Cy) is widely used as an effective cytotoxic drug, but its use limited because of toxicity. In this report, we describe for the first time ability purified protein A (P) Staphylococcus aureus to reduce Cy-induced toxicity in rats. Protein A-treated animals recover quickly from toxic effects Cy. The antitumor property Cy not reduced P+Cy group. fact, latter showed a persistent decrease tumor volume compared with may prove be agent increasing therapeutic index
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