[Taurine is a possible anti-atherosclerotic agent].
作者： Takashi ITO , Junichi AZUMA
DOI: 10.1254/FPJ.123.311
关键词: Endocrinology 、 Myeloperoxidase 、 Endothelial dysfunction 、 Chemistry 、 Endothelium 、 Very low-density lipoprotein 、 Internal medicine 、 Lipid peroxidation 、 Taurine 、 Monocyte 、 Hypochlorous acid
摘要: Atherosclerosis-related ischemic heart diseases are the principal cause of death in last few years. Recently, several reports implicated that taurine, sulfur-containing beta-amino acid, prevented progression atherosclerosis through various anti-pathogenetic modifications. Firstly, taurine treatment inhibited lipid peroxidation and/or lowered serum LDL/VLDL cholesterol and elevated HDL, as a result, it accumulation on aortic valve hypercholesterolaemic animals. Secondly, administration endothelial dysfunction, one initial events formation lesions atherosclerosis, amelioration impairment monocyte function. Thirdly, while is well known scavenges hypochlorous acid (HOCl) produced by myeloperoxidase neutrophils macrophages, recent studies revealed HOCl was major factors oxidizing LDL, implying anti-oxidative role contributes to anti-atherosclerotic effect. Additionally, TauCl, reaction with HOCl, inhibits activation NF-kappaB followed inhibition production pro-inflammatory mediators.
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