LncRNA LEF1-AS1 promotes osteogenic differentiation of dental pulp stem cells via sponging miR-24-3p.
作者： Yuexia Wu , Keqian Lian , Cong Sun
DOI: 10.1007/S11010-020-03868-7
关键词: Dental pulp stem cells 、 Bone regeneration 、 Cell biology 、 Chemistry 、 Mir 24 3p 、 Function (biology)
摘要: The role of lncRNA LEF1-AS1 in the regulation osteogenic differentiation dental pulp stem cells (DPSCs) is still obscure. Here, we demonstrated that LncRNA expression was associated with DPSCs and overexpression promoted differentiation. Moreover, miR-24-3p could directly regulate each other acted as sponge partner miR-24-3p. Furthermore, synergized to DPSCs. Finally, verified TGFBR1 direct target miR-24-3p/LEF1-AS1 sponged expression. Our study revealed a novel mechanism about how did execute function osteogenesis thus might serve potential therapeutic for bone regeneration pulp.
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