Mechanisms of Endothelial Protection by Natural Bioactive Compounds from Fruit and Vegetables.

摘要: The endothelium is fundamental for the regulation of vascular tone and structure. Under disease conditions, including presence cardiovascular risk factors, loses its protective role becomes a proatherosclerotic In this article we searched strategies from PUBMED Science Direct databases using following key words: endothelium, natural bioactive compounds, polyphenols diseases. search was restricted to english language papers. Studies have identified contribution diet developing context, high intakes fruit vegetables are associated with decrease Thus most important fruit/vegetables compounds prevent endothelial diseases berries, apples, virgin olive oil, tomatoes, soybeans, polyphenols, carotenoids unsaturated fatty acids, respectively. provide protection through mechanisms: improved eNOS/NO bioavailability, attenuates oxidative stress, inhibited NF-κB pathway decreased cell adhesion molecules expression. compound mechanisms thoroughly reviewed.