Base excision DNA repair.
作者： D. O. Zharkov
DOI: 10.1007/S00018-008-7543-2
关键词: Biology 、 DNA glycosylase 、 Excinuclease 、 Base excision repair 、 Computational biology 、 Biochemistry 、 AP endonuclease 、 Very short patch repair 、 AP site 、 DNA repair 、 Nucleotide excision repair
摘要: DNA repair is a collection of several multienzyme, multistep processes keeping the cellular genome intact against genotoxic insults. One these base excision repair, which deals with most ubiquitous lesions in DNA: oxidative damage, alkylation, deamination, sites loss and single-strand breaks, etc. Individual enzymes acting have been identified. The recent years were marked many advances understanding their structure interactions that make functional, versatile system. This review describes current knowledge structural biology biochemistry individual steps subpathways common pathway, process other processes.
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