Nitric oxide donors, nitrosothiols and mitochondrial respiration inhibitors induce caspase activation by different mechanisms

作者: Vilmante Borutaite , Ramune Morkuniene , Guy C. Brown

DOI: 10.1016/S0014-5793(00)01140-6

关键词: Cyclosporin aCytochrome cCalciumMitochondrial permeability transition poreBiologyNONOateCaspaseMitochondrionNitric oxideCell biology

摘要: We investigated to what extent different types of NO donors induce caspase activation by opening the mitochondrial permeability transition pore (PTP) or inhibition respiration. found that nitrosothiols can directly open PTP in isolated mitochondria and cause cytochrome c release, whereas NONOate not. In macrophages is blocked cyclosporin A calcium chelation, both which prevent opening, caused NONOates much less sensitive these agents. Inhibitors respiration did not promote mitochondria, although they macrophages, this was slower than donors, relatively insensitive chelators suggesting involved.

参考文章(25)
Udo K MESSMER, Bernhard BRÜNE, Nitric oxide-induced apoptosis: p53-dependent and p53-independent signalling pathways. Biochemical Journal. ,vol. 319, pp. 299- 305 ,(1996) , 10.1042/BJ3190299
J.S. Rieske, [76] The quantitative determination of mitochondrial hemoproteins Methods in Enzymology. ,vol. 10, pp. 488- 493 ,(1967) , 10.1016/0076-6879(67)10081-5
Carl Nathan, Nitric oxide as a secretory product of mammalian cells. The FASEB Journal. ,vol. 6, pp. 3051- 3064 ,(1992) , 10.1096/FASEBJ.6.12.1381691
Udo K. Meβmer, John C. Reed, Bernhard Brüne, Bcl-2 Protects Macrophages from Nitric Oxide-induced Apoptosis Journal of Biological Chemistry. ,vol. 271, pp. 20192- 20197 ,(1996) , 10.1074/JBC.271.33.20192
Sonsoles Hortelano, Bruno Dallaporta, Naoufal Zamzami, Tamara Hirsch, Santos A Susin, Isabel Marzo, Lisardo Boscá, Guido Kroemer, Nitric oxide induces apoptosis via triggering mitochondrial permeability transition FEBS Letters. ,vol. 410, pp. 373- 377 ,(1997) , 10.1016/S0014-5793(97)00623-6
Maxim Yu. Balakirev, Valery V. Khramtsov, Guido Zimmer, Modulation of the Mitochondrial Permeability Transition by Nitric Oxide FEBS Journal. ,vol. 246, pp. 710- 718 ,(1997) , 10.1111/J.1432-1033.1997.00710.X
Guy C Brown, Nitric oxide and mitochondrial respiration. Biochimica et Biophysica Acta. ,vol. 1411, pp. 351- 369 ,(1999) , 10.1016/S0005-2728(99)00025-0
Sonsoles Hortelano, Eduardo López-Collazo, Lisardo Boscá, Protective effect of cyclosporin A and FK506 from nitric oxide-dependent apoptosis in activated macrophages. British Journal of Pharmacology. ,vol. 126, pp. 1139- 1146 ,(1999) , 10.1038/SJ.BJP.0702422
Stefanie Dimmeler, Andreas M. Zeiher, Nitric Oxide and Apoptosis: Another Paradigm for the Double-Edged Role of Nitric Oxide Nitric Oxide. ,vol. 1, pp. 275- 281 ,(1997) , 10.1006/NIOX.1997.0133