Reciprocal Interactions between Lactoferrin and Bacterial Endotoxins and Their Role in the Regulation of the Immune Response
作者： Daniela Latorre , Patrizia Puddu , Piera Valenti , Sandra Gessani
关键词: Innate immune system 、 Glycoprotein 、 Biology 、 Cell activation 、 Immune system 、 Cell biology 、 Inflammation 、 Lactoferrin 、 Immunology 、 Receptor 、 Lipopolysaccharide
摘要: Lactoferrin (Lf), an iron-binding glycoprotein expressed in most biological fluids, represents a major component of the mammalian innate immune system. Lf’s multiple activities rely not only on its capacity to bind iron, but also interact with molecular and cellular components both host pathogens. Lf can sequester lipopolysaccharide (LPS), thus preventing pro-inflammatory pathway activation, sepsis tissue damage. However, Lf-bound LPS may retain induce cell activation via Toll-like receptor 4-dependent -independent mechanisms. This review discusses complex interplay between relevance regulation response.
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