Preventive effect of recombinant human lactoferrin on lipopolysaccharide-induced preterm delivery in mice.
作者： Yasushi Sasaki , Katsufumi Otsuki , Akitoshi Hasegawa , Maki Sawada , Hiroshi Chiba
DOI: 10.1111/J.0001-6349.2004.00587.X
关键词:
摘要: Background. In order to investigate whether recombinant human lactoferrin (rh-LF) has the same effect as bovine LF (b-LF) for prevention of preterm delivery, we conducted following animal studies. Methods. Female C3H/HeNCrj mice were pair-mated with male Crj:B6D2F1 mice. As a model on day 15 gestation, 50 µg/kg intraperitoneal injection lipopolysaccharide (LPS) was administered twice 3-hr interval between injections (14:00 and 17:00 hours). At 1 hr prior each LPS (13:00 16:00 hours), an saline, b-LF, or rh-LF (1 mg/body) administered. non-LPS-treated controls, saline four times (13:00, 14:00, 16:00, We measured body weight recorded delivery time. To measure plasma levels interleukin-6 (IL-6), other pregnant mice, in which preparation mentioned above had been done, killed 6 h after second blood sampl...
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