The Relationship between Leptin Concentration and Bone Metabolism in the Human Fetus
作者： O. Ogueh , S. Sooranna , K. H. Nicolaides , M. R. Johnson
关键词: Fetus 、 Internal medicine 、 Biology 、 Leptin 、 Blood plasma 、 Bone remodeling 、 N-terminal telopeptide 、 Bone resorption 、 Adipose tissue 、 Gestational age 、 Endocrinology
摘要: This study investigates the relationship between leptin and fetal bone metabolism by measuring blood levels of leptin, carboxy-terminal pro-peptide type I pro-collagen (PICP; a marker formation) cross-linked telopeptide collagen (ICTP; resorption). The median gestational age at time sampling was 23 weeks (range, 18-35). There positive correlation concentration (r = 0.543, P < 0.001) negative both PICP ICTP -0.592 r -0.550, respectively, 0.001 for both). Also, there concentrations -0.260, 0.022) -0.622, 0.001). Using multiple regression analysis, positively correlated to 0.240, 0.042) negatively -0.420, increase in with is consistent adipose tissue development subsequent accumulation fat mass. suggests that may decrease resorption overall effect increasing Therefore, play role as part its on growth development.
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