FAAH deficiency promotes energy storage and enhances the motivation for food

摘要: Fatty acid amide hydrolase (FAAH) is the main degrading enzyme of fatty ethanolamides anandamide (AEA) and oleoylethanolamide (OEA), which have opposite effects on food intake energy balance. AEA, an endogenous ligand CB1 cannabinoid receptors, enhances storage, whereas OEA binds to peroxisome proliferator-activated receptors-α reduce promoting lipolysis. To elucidate role FAAH in balance, we evaluated different metabolic behavioral responses related feeding FAAH-deficient (FAAH−/−) mice their wild-type littermates. Total daily was similar both genotypes, but high-fat consumption enhanced during dark hours decreased light FAAH−/− mice. The reinforcing motivational were also as revealed by operant paradigms. These reversed administration selective antagonist rimonabant. Furthermore, body weight, total amount adipose tissue, plasma-free acids triglyceride content plasma, liver, skeletal muscle increased Accordingly, leptin levels adiponectin these mutants, showed plasma insulin blood glucose revealing resistance. As expected, AEA hypothalamus, small intestine liver results indicate that lack predominantly promotes storage intake-independent mechanisms, through enhancement rather than anorexic OEA.