Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α
作者： Jin Fu , Silvana Gaetani , Fariba Oveisi , Jesse Lo Verme , Antonia Serrano
DOI: 10.1038/NATURE01921
关键词:
摘要: Oleylethanolamide (OEA) is a naturally occurring lipid that regulates satiety and body weight 1 , 2 . Although structurally related to the endogenous cannabinoid anandamide, OEA does …
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Paul R. Colville-Nash, Saima S. Qureshi, Dean Willis, Derek A. Willoughby, Inhibition of Inducible Nitric Oxide Synthase by Peroxisome Proliferator-Activated Receptor Agonists: Correlation with Induction of Heme Oxygenase 1 Journal of Immunology. ,vol. 161, pp. 978- 984 ,(1998)
Pascal Escher, Olivier Braissant, Sharmila Basu-Modak, Liliane Michalik, Walter Wahli, Béatrice Desvergne, Rat PPARs: quantitative analysis in adult rat tissues and regulation in fasting and refeeding. Endocrinology. ,vol. 142, pp. 4195- 4202 ,(2001) , 10.1210/ENDO.142.10.8458
Timothy M. Willson, Peter J. Brown, Daniel D. Sternbach, Brad R. Henke, The PPARs: from orphan receptors to drug discovery. Journal of Medicinal Chemistry. ,vol. 43, pp. 527- 550 ,(2000) , 10.1021/JM990554G
B. M. Forman, J. Chen, R. M. Evans, Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 4312- 4317 ,(1997) , 10.1073/PNAS.94.9.4312
A. Stricker-Krongrad, B. Beck, C. Burlet, Nitric oxide mediates hyperphagia of obese zucker rats: Relation to specific changes in the microstructure of feeding behavior Life Sciences. ,vol. 58, ,(1995) , 10.1016/0024-3205(95)02260-0
William A Devane, Lumir Hanuš, Aviva Breuer, Roger G Pertwee, Lesley A Stevenson, Graeme Griffin, Dan Gibson, Asher Mandelbaum, Alexander Etinger, Raphael Mechoulam, ISOLATION AND STRUCTURE OF A BRAIN CONSTITUENT THAT BINDS TO THE CANNABINOID RECEPTOR Science. ,vol. 258, pp. 1946- 1949 ,(1992) , 10.1126/SCIENCE.1470919
Alicia J Jenkins, James D Best, Novel agents for managing dyslipidaemia. Expert Opinion on Investigational Drugs. ,vol. 10, pp. 1901- 1911 ,(2001) , 10.1517/13543784.10.11.1901
Kiyoto Motojima, Patricia Passilly, Jeffrey M. Peters, Frank J. Gonzalez, Norbert Latruffe, Expression of Putative Fatty Acid Transporter Genes Are Regulated by Peroxisome Proliferator-activated Receptor α and γ Activators in a Tissue- and Inducer-specific Manner Journal of Biological Chemistry. ,vol. 273, pp. 16710- 16714 ,(1998) , 10.1074/JBC.273.27.16710
Béatrice Desvergne, Walter Wahli, Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocrine Reviews. ,vol. 20, pp. 649- 688 ,(1999) , 10.1210/EDRV.20.5.0380
Geneviève Martin, Kristina Schoonjans, Anne-Marie Lefebvre, Bart Staels, Johan Auwerx, Coordinate Regulation of the Expression of the Fatty Acid Transport Protein and Acyl-CoA Synthetase Genes by PPARα and PPARγ Activators Journal of Biological Chemistry. ,vol. 272, pp. 28210- 28217 ,(1997) , 10.1074/JBC.272.45.28210