Intrathecal induces hyperexcitability in rat dorsal horn convergent neurones
作者： Graham D. Sher , Duncan Mitchell
DOI: 10.1016/0304-3940(90)90833-U
关键词: Chemistry 、 Neuroscience 、 Diffuse noxious inhibitory control 、 Spinal cord 、 Spinal Cord Dorsal Horn 、 Hyperalgesia 、 Nociception 、 Inhibitory postsynaptic potential 、 Excitatory postsynaptic potential 、 NMDA receptor
摘要: Abstract We have investigated the effects of intrathecal (i.t.) N- methyl- d -aspartate (NMDA) and an NMDA antagonist -2-amino-5-phosphonovalerate (APV) on spontaneous evoked activity in rat dorsal horn convergent neurones. Extracellular recordings were made from 54 neurones located both superficial deep horn. induced a dose-dependent increase firing rate neurones, with 1 μM mM producing rates significantly greater than i.t. saline. In addition, hyperexcitability to subsequent noxious mechanical stimuli at mM, innocuous mM. The NMDA-induced was reversed by pretreatment APV Diffuse inhibitory controls (DNIC) applied areas body remote receptive field also inhibited effects. There no difference between responses suggesting uniform excitatory action Our results support role for receptor mediating central component hyperalgesia, level spinal cord
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