Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following c fibre stimulation.
作者： A.H. Dickenson , Ann F. Sullivan
DOI: 10.1016/0028-3908(87)90275-9
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摘要: Abstract Ten nociceptive neurones located deep (〉640μm) in the dorsal horn of intact halothane anaesthetized rat were activated by transcutaneous electrical stimulation their receptive fields producing short latency Aβ and C fibre evoked activity. Repetitive (16 stimuli at 0.5Hz) produced “wind up”, an increase activity with suceeding consequently post discharges neurones. Direct application aminophosphonovaleric acid (AP5) onto cord surface (250 or 500μg) minor changes A inputs cells but reliably reduced up” The results suggest involvement NMDA receptor this potentiation
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Jens Schouenborg, Anthony Dickenson, The effects of a distant noxious stimulation on A and C fibre-evoked flexion reflexes and neuronal activity in the dorsal horn of the rat Brain Research. ,vol. 328, pp. 23- 32 ,(1985) , 10.1016/0006-8993(85)91318-6
Caroline E. Herron, Robin A. J. Lester, Elizabeth J. Coan, Graham L. Collingridge, Frequency-dependent involvement of NMDA receptors in the hippocampus: a novel synaptic mechanism Nature. ,vol. 322, pp. 265- 268 ,(1986) , 10.1038/322265A0
L. Nowak, P. Bregestovski, P. Ascher, A. Herbet, A. Prochiantz, Magnesium gates glutamate-activated channels in mouse central neurones Nature. ,vol. 307, pp. 462- 465 ,(1984) , 10.1038/307462A0
R. G. M. Morris, E. Anderson, G. S. Lynch, M. Baudry, Selective impairment of learning and blockade of long-term potentiation by an N -methyl-D-aspartate receptor antagonist, AP5 Nature. ,vol. 319, pp. 774- 776 ,(1986) , 10.1038/319774A0
P M Headley, C G Parsons, D C West, The role of N-methylaspartate receptors in mediating responses of rat and cat spinal neurones to defined sensory stimuli. The Journal of Physiology. ,vol. 385, pp. 169- 188 ,(1987) , 10.1113/JPHYSIOL.1987.SP016490
G L Collingridge, S J Kehl, H McLennan, Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus. The Journal of Physiology. ,vol. 334, pp. 33- 46 ,(1983) , 10.1113/JPHYSIOL.1983.SP014478
Anthony H. Dickenson, Ann F. Sullivan, Electrophysiological studies on the effects of intrathecal morphine on nociceptive neurones in the rat dorsal horn. Pain. ,vol. 24, pp. 211- 222 ,(1986) , 10.1016/0304-3959(86)90044-8
Lorne M. Mendell, Physiological properties of unmyelinated fiber projection to the spinal cord Experimental Neurology. ,vol. 16, pp. 316- 332 ,(1966) , 10.1016/0014-4886(66)90068-9