Limited Joint Mobility in Childhood Diabetes: Family Studies

摘要: We examined 204 persons with insulin-dependent diabetes mellitus (IDDM), aged 7–23 yr, and 336 of their first-degree relatives, to determine whether there is a genetic component the development limited joint mobility. Simple multiplex pedigrees IDDM were studied along normal controls. Only 1 90 controls had stiffness. Among 225 nondiabetic parents children IDDM, 7 (3%) limitation, compared 42 (21%) youth IDDM. 108 siblings diabetic probands limitation. Three adult-onset all None 8 relatives limitation involvement; 5 these tested negative for islet cell auto-antibodies. There 11 families at least one member having The concordance rate mobility more than yr who over 12 age was 56%, not different from 48% frequency in patients met duration criteria. Thus, evidence that metabolic consequence includes virtual absence among probands, including stiffness, involvement increased Furthermore, two brothers pancreatic hypoplasia non-HLA-associated form affected Nonetheless, expression this complication must be influenced by host factors, since develop it, those do have variable ages onset without correlation control measures.