Primary gastric synovial sarcoma: molecular diagnosis and prediction of prognosis

摘要: A 42-year-old Japanese woman complained of upper abdominal pain. Endoscopic examination demonstrated an elevated lesion in the body stomach, and a biopsy specimen proliferation atypical spindle cells. She underwent partial gastrectomy; resected tumor measured 3.5 × 2.8 1.2 cm size. Histological disclosed haphazard cells mucosa mixed with less prominent epithelioglandular component. The were positive for cytokeratin, vimentin, EMA CD99, but not KIT, DOG1, desmin or S100. Reverse transcription-polymerase chain reaction using paraffin sections amplified SYT-SSX1 chimera transcript. diagnosis synovial sarcoma was made. There has been no sign recurrence metastasis 6 years after operation. Synovial stomach is very rare. Since differential from carcinosarcoma mesenchymal tumors critical treatment prediction prognosis, accurate molecular analysis essential.